X-ray structure of the NO-bound CuB in bovine cytochrome c oxidase
March 11th, 2010 Posted by: admin
The X-ray crystallographic structure of nitric oxide-treated bovine heart cytochrome c oxidase (CcO) in the fully reduced state has been determined at 50 K under light illumination. In this structure, nitric oxide (NO) is bound to the CcO oxygen-reduction site, which consists of haem and a Cu atom (the haem a3[ndash]CuB site). Electron density for the NO molecule was observed close to CuB. The refined structure indicates that NO is bound to CuB in a side-on manner.
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