Usefulness of Soluble Fms-like Tyrosine Kinase-1 as a Biomarker of Acute Severe Heart Failure in Patients With Acute Myocardial Infarction
November 24th, 2009 Posted by: admin
Publication year: 2009
Source: The American Journal of Cardiology, Volume 104, Issue 11, 1 December 2009, Pages 1478-1483
Kenji, Onoue , Shiro, Uemura , Yukiji, Takeda , Satoshi, Somekawa , Hajime, Iwama , …
Placental growth factor and vascular endothelial growth factor increase angiogenesis and promote healing after acute myocardial infarction (MI), but the significance of soluble Fms-like tyrosine kinase-1 (sFlt-1), an antagonist of placental growth factor and vascular endothelial growth factor, in the setting of acute MI has not been elucidated. The development of acute heart failure in the immediate period after MI is a dreaded complication, but there are no useful biomarkers that identify patients at risk of acute heart failure. We wished to investigate the clinical significance of circulating sFlt-1 during acute MI. We enrolled 174 patients with acute MI, and…
