"iDoctor – Medical Blog"

Sugar-sweetened beverage consumption and the progression of chronic kidney disease in the Multi-Ethnic Study of Atherosclerosis (MESA).

Am J Clin Nutr. 2009 Sep 9;

Authors: Bomback AS, Katz R, He K, Shoham DA, Burke GL, Klemmer PJ

BACKGROUND: Recent studies have examined sugar soda consumption in relation to early markers of kidney disease, but to date there have been no investigations of whether sugar-sweetened beverage consumption affects preexistent chronic kidney disease (CKD). OBJECTIVE: This prospective cohort study of 447 participants in the Multi-Ethnic Study of Atherosclerosis (MESA) with preexistent CKD examined the association between sugar-sweetened beverage consumption (<1 drink/wk, 1-6 drinks/wk, and >/=1 drink/d) and progression of CKD. DESIGN: beta-Coefficients for continuous outcomes of changes in eGFR and urinary albumin to creatinine ratio (UACR) were calculated by using linear regression. Odds ratios for binary outcomes of accelerated decline in estimated glomerular filtration rate (eGFR), defined as >2 mL . min(-1) . 1.73 m(-2) per year, and clinically significant progression of albuminuria (defined as attainment of UACR >/=30 mg/g for participants without microalbuminuria at visit 1 or a >/=25% increase in UACR for participants with baseline microalbuminuria) were evaluated by using logistic regression. RESULTS: The mean (+/-SD) baseline eGFR was 52 +/- 6 mL min(-1) 1.73 m(-2) per year and median baseline UACR was 6.3 mg/g (interquartile range: 3.5-17.6). Univariate and multivariate analyses showed no association between sugar-sweetened beverage consumption and rate of eGFR decline or changes in urinary albumin to creatinine ratio. The multivariate odds ratios comparing participants who drank >/=1 sugary beverage daily with those who drank </=1 beverage weekly were 0.62 (95% CI: 0.27, 1.41) for accelerated eGFR decline and 1.51 (95% CI: 0.49, 4.62) for clinically significant progression of albuminuria. CONCLUSION: A higher consumption of sugar-sweetened beverages was not associated with disease progression, on the basis of either eGFR or the urinary albumin to creatinine ratio, in MESA participants with preexistent CKD.

PMID: 19740973 [PubMed - as supplied by publisher]

This entry was posted on Sunday, September 13th, 2009 at 3:14 am and is filed under Health news. You can follow any responses to this entry through the RSS 2.0 feed. You can skip to the end and leave a response. Pinging is currently not allowed.