Structure of TTHA1623, a novel metallo-β-lactamase superfamily protein from Thermus thermophilus HB8
June 4th, 2009 Posted by: admin
TTHA1623 is a metallo-[beta]-lactamase superfamily protein from the extremely thermophilic bacterium Thermus thermophilus HB8. Homologues of TTHA1623 exist in a wide range of bacteria and archaea and one eukaryote, Giardia lamblia, but their function remains unknown. To analyze the structural properties of TTHA1623, the crystal structures of its iron-bound and zinc-bound forms have been determined to 2.8 and 2.2 Å resolution, respectively. TTHA1623 possesses an [alpha][beta][beta][alpha]-fold similar to that of other metallo-[beta]-lactamase superfamily proteins with glyoxalase II-type metal coordination. However, TTHA1623 exhibits a putative substrate-binding pocket with a unique shape.
