Results of Intracoronary Stem Cell Therapy After Acute Myocardial Infarction
February 7th, 2010 Posted by: admin
Publication year: 2010
Source: The American Journal of Cardiology, In Press, Corrected Proof, Available online 5 February 2010
Jochen, Wöhrle , Nico, Merkle , Volker, Mailänder , Thorsten, Nusser , Peter, Schauwecker , …
To assess the effect of autologous bone-marrow cell (BMC) therapy in patients with acute myocardial infarction in a rigorous double-blind, randomized, placebo-controlled trial. Patients with reperfusion >6 hours after symptom onset were randomly assigned in a 2:1 ratio to receive intracoronary BMC or placebo therapy 5 to 7 days after symptom onset. The patients were stratified according to age, acute myocardial infarction localization, and left ventricular (LV) function. Rigorous double-blinding was ensured using autologous erythrocytes for the placebo preparation that was visually indistinguishable from the active treatment. Serial cardiac magnetic resonance imaging studies were performed before study therapy and after…
