"iDoctor – Medical Blog"

Publication year: 2010
Source: The American Journal of Cardiology, Volume 105, Issue 1, Supplement 1, 4 January 2010, Pages 30A-35A
Byron J., Hoogwerf

The renin–angiotensin–aldosterone system (RAAS) plays an important role in the pathogenesis of a variety of clinical conditions, including atherosclerosis, hypertension, left ventricular hypertrophy, myocardial infarction, and heart failure. Inhibition of the RAAS with either angiotensin-converting enzyme inhibitors or angiotensin receptor blockers (ARBs) has been shown to be effective in lowering blood pressure and reducing cardiovascular mortality and morbidity in various at-risk patient populations. A number of studies have shown that these 2 classes are effective in reducing the rate of renal disease progression in patients with diabetic nephropathy, although more long-term vascular outcome studies are needed in patients with chronic…

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