Relation of Race (Asian, African-American, European-American, and Hispanic) to Activated Clotting Time After Weight-Adjusted Bolus of Heparin During Percutaneous Coronary Intervention
February 25th, 2010 Posted by: admin
Publication year: 2010
Source: The American Journal of Cardiology, Volume 105, Issue 5, 1 March 2010, Pages 629-632
Yuichi J., Shimada , Navin C., Nakra , John T., Fox , Yumiko, Kanei
A weight-adjusted bolus of heparin (70 to 100 IU/kg) is recommended to achieve adequate anticoagulation during percutaneous coronary intervention (PCI). Proper dosing is mandatory to avoid bleeding and thrombotic complications. We investigated whether sensitivity to heparin is affected by difference in race. We performed a retrospective study with 874 consecutive PCI cases in our catheterization laboratory. The amount of initial heparin bolus (international units) per weight and subsequent activated clotting time (ACT; seconds) were obtained. Patients were divided into 4 categories based on race: Asian, African-American, European-American, and Hispanic. Multiple regression analysis was performed to validate the variables that determine…
