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Publication year: 2010
Source: The American Journal of Cardiology, Volume 105, Issue 4, 15 February 2010, Pages 459-466

Naser, Ahmadi , Sotirios, Tsimikas , Fereshteh, Hajsadeghi , Anila, Saeed , Vahid, Nabavi , …

The relation between oxidative stress and coronary artery calcium (CAC) progression is currently not well described. The present study evaluated the relation among the biomarkers of oxidative stress, vascular dysfunction, and CAC. Sixty asymptomatic subjects participated in a randomized trial evaluating the effect of aged garlic extract plus supplement versus placebo and underwent measurement of CAC. The postcuff deflation temperature-rebound index of vascular function was assessed using a reactive hyperemia procedure. The content of oxidized phospholipids (OxPL) on apolipoprotein B-100 (apoB) particles detected by antibody E06 (OxPL/apoB), lipoprotein(a), IgG and IgM autoantibodies to malondialdehyde–low-density lipoprotein and apoB-immune complexes were measured…

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