Relation of N-Terminal Pro-B-Type Natriuretic Peptide to Symptoms, Severity, and Left Ventricular Remodeling in Patients With Organic Mitral Regurgitation
June 27th, 2009 Posted by: admin
Publication year: 2009
Source: The American Journal of Cardiology, In Press, Corrected Proof, Available online 18 June 2009
Benjamin D., Shaw, Mihael, Potocki , Johannes, Mair , Michael, Weber , Christian, Hamm , …
Natriuretic peptides reflect cardiac stress and may therefore be useful in the management of patients with valvular heart disease. Data regarding these biomarkers in organic mitral regurgitation (MR) are sparse. In this study, 144 patients with moderate or severe organic MR were prospectively enrolled in an observational, multicenter study to analyze the relation of N-terminal–pro-B-type natriuretic peptide (NT–pro-BNP) to symptoms, severity of MR, and echocardiographic parameters. NT–pro-BNP levels (median 373 pg/ml, interquartile range 150 to 997) were associated with age, gender, creatinine, New York Heart Association (NYHA) functional class, atrial fibrillation, left ventricular (LV) end-systolic dimension, and the LV ejection…
