Relation of Body Mass Index to Sudden Cardiac Death and the Benefit of Implantable Cardioverter–Defibrillator in Patients With Left Ventricular Dysfunction After Healing of Myocardial Infarction
January 23rd, 2010 Posted by: admin
Publication year: 2010
Source: The American Journal of Cardiology, In Press, Corrected Proof, Available online 22 January 2010
Bonnie, Choy , Eric, Hansen , Arthur J., Moss , Scott, McNitt , Wojciech, Zareba , …
Obesity has been identified as a risk factor for cardiovascular disease and heart failure. However, data regarding the relation of body mass index (BMI) to outcome in patients with established heart failure are conflicting. We examined the risk of all-cause mortality and sudden cardiac death (SCD) in 1,231 patients after myocardial infarction with left ventricular dysfunction enrolled the Multicenter Automatic Defibrillator Implantation Trial-II (MADIT-II). Interaction-term analysis was used to assess the benefit of the implantable cardioverter–defibrillator (ICD) in upper (obese ≥30 kg/m2, n = 361) and lower (nonobese <30 kg/m2, n = 870) BMI categories. Mean BMI in the study…
