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Publication year: 2010
Source: The American Journal of Cardiology, Volume 105, Issue 1, Supplement 1, 4 January 2010, Pages 10A-20A
Jeffrey L., Probstfield , Kevin D., O’Brien

The renin–angiotensin system (RAS) plays key roles throughout the cardiovascular continuum, and blockade of this system—either through angiotensin-converting enzyme (ACE) inhibition or through angiotensin II type 1 (AT1) receptor antagonism—now occupies a central place in the management of cardiovascular disease (CVD). Understanding of the RAS has expanded in recent years with the identification of new pathways for formation of angiotensin II and novel effector peptides, such as angiotensin-(1–7), which may constitute new therapeutic targets. A substantial proportion of the benefits of ACE inhibitors, including vasodilation, improvements in endothelial function, and inhibition of cell proliferation, appear to be attributable to decreases…

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