Pleiotropy of C-Reactive Protein Gene Polymorphisms With C-Reactive Protein Levels and Heart Rate Variability in Healthy Male Twins
December 4th, 2009 Posted by: admin
Publication year: 2009
Source: The American Journal of Cardiology, Volume 104, Issue 12, 15 December 2009, Pages 1748-1754
Shaoyong, Su , Rachel, Lampert , Jinying, Zhao , James Douglas, Bremner , Andrew, Miller , …
Reduced heart rate variability (HRV) and increased C-reactive protein (CRP) levels are both predictors of coronary artery disease and correlate with each other. We examined whether these 2 phenotypes share a common genetic substrate and investigated the relations of the CRP gene polymorphisms with both CRP levels and HRV indexes. We examined 236 male twins free of symptomatic coronary artery disease, with a mean age ± SD of 54 ± 2.9 years. The plasma CRP levels were measured and the frequency domain measures of HRV were assessed using a 24-hour electrocardiographic recording, including ultra-low-, very-low-, low-, and high-frequency power. Three…
