Morphological and immunohistochemical characterization of paraneoplastic cerebellar degeneration associated with Yo antibodies
June 4th, 2009 Posted by: admin
Storstein A, Krossnes BK, Vedeler CA. Morphological and immunohistochemical characterization of paraneoplastic cerebellar degeneration associated with Yo antibodies.Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2008.01138.x.© 2009 The Authors Journal compilation © 2009 Blackwell Munksgaard.Introduction [ndash] Immunohistochemical studies of paraneoplastic cerebellar degeneration (PCD) are rare, and the findings vary.Materials and methods [ndash] We performed morphological and immunohistochemical characterization of the brain, medulla and tumour of two patients with PCD, Yo antibodies and ovarian adenocarcinoma.Results [ndash] The cerebellum of both patients had extensive loss of Purkinje cells. Microglia activation and T cells were found in the cerebellum, but B cells or deposits of IgG or complement were not detected. Microglia activation was also present in the brain stem and medulla. T cells were found in the ovarian adenocarcinoma.Conclusion [ndash] PCD is characterized by loss of Purkinje cells and microglia activation, and the presence of T cells indicates cellular immune reactions in PCD and in ovarian cancer.
