Metallic Stent Placement in the Palliative Treatment of Malignant Gastric Outlet Obstructions: Primary Gastric Carcinoma Versus Pancreatic Carcinoma
June 25th, 2009 Posted by: admin
OBJECTIVE. The objective of our study was to compare the clinical
effectiveness of metallic stent placement for relief of gastric outlet
obstruction caused by gastric carcinoma and pancreatic carcinoma.
MATERIALS AND METHODS. A total of 207 patients with gastric outlet
obstruction caused by inoperable gastric carcinoma (n = 147) or
pancreatic carcinoma (n = 60) underwent metallic stent placement.
RESULTS. Technical success of metallic stent placement was achieved
in all patients. Clinical success was achieved in 97% and 93% of patients with
gastric and pancreatic carcinoma, respectively (p = 0.286). The
overall complication rate did not differ significantly between the gastric
(29%) and pancreatic (23%) carcinoma groups (p = 0.441). Stent
collapse was significantly more frequent in the gastric carcinoma group (11%)
than the pancreatic carcinoma group (2%) (p = 0.027), whereas serious
complications, including gastrointestinal bleeding and intestinal perforation,
occurred more frequently in the pancreatic (7%) than the gastric (1%)
carcinoma group (p = 0.026). The cumulative survival period was
significantly longer in the gastric carcinoma (median, 153 days) than the
pancreatic carcinoma (median, 90 days) group (p = 0.041), but
cumulative stent patency did not differ significantly between the gastric
carcinoma (median, 350 days) and pancreatic carcinoma (median, 385 days)
groups (p = 0.415).
CONCLUSION. Metallic stent placement was clinically effective in the
palliative treatment of gastric outlet obstruction in patients with gastric
and pancreatic carcinoma. The two groups differed significantly in the rates
of stent collapse and serious complications and patient survival after stent
placement.
