Meta-Analysis of Randomized Controlled Trials of Statins Versus Placebo in Patients With Heart Failure
December 5th, 2009 Posted by: admin
Publication year: 2009
Source: The American Journal of Cardiology, Volume 104, Issue 12, 15 December 2009, Pages 1708-1716
Michael J., Lipinski , Clay A., Cauthen , Giuseppe G.L., Biondi-Zoccai , Antonio, Abbate , Bojan, Vrtovec , …
Although statins have been shown to improve outcomes in retrospective analyses of patients with heart failure (HF), recent randomized placebo-controlled trials have shown mixed results. The goal of this study was to systematically review randomized trials comparing statins to placebo for HF and compare the impact of different statins. CENTRAL, mRCT, and PubMed were searched for eligible studies that prospectively randomized patients with HF to statins or placebo. Primary end points were all-cause mortality, cardiovascular mortality, hospitalization for worsening HF, adverse drug events, and changes in left ventricular ejection fraction (LVEF). Pooling was performed with random effect methods with summary…
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