"iDoctor – Medical Blog"

Publication year: 2009<br><b>Source:</b> The American Journal of Cardiology, Volume 104, Issue 10, Supplement 1, 16 November 2009, Pages 10E-15E<br>Philip, Barter<br><br>Inhibition of the cholesteryl ester transfer protein (CETP), a plasma protein that normally transfers cholesterol from the protective high-density lipoprotein (HDL) fraction to the atherogenic low-density lipoprotein (LDL) fraction, results in an increase in the concentration of HDL cholesterol and a decrease in the concentration of LDL cholesterol and has been shown in rabbits to inhibit the development of atherosclerosis. The CETP inhibitor torcetrapib was investigated in humans in imaging trials that failed to demonstrate an effect on atheroma in either the carotid or coronary arteries. When tes

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