Immunoglobulin IgG Fc-receptor polymorphisms and HLA class II molecules in Guillain–Barré syndrome
January 26th, 2010 Posted by: admin
Sinha S, Prasad KN, Jain D, Nyati KK, Pradhan S, Agrawal S. Immunoglobulin IgG Fc-receptor polymorphisms and HLA class II molecules in Guillain[ndash]Barré syndrome.Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2009.01229.x.© 2010 The Authors Journal compilation © 2010 Blackwell Munksgaard.Objective [ndash] To analyze host genetic factors immunoglobulin G Fc receptors (Fc[gamma]Rs) and human leukocyte antigen (HLA) class II in GBS patients.Methods [ndash] Fc[gamma]RIIA, IIIA and IIIB polymorphisms were studied in 80 each GBS patients and healthy controls by allele specific PCR. HLA class II DR[beta]1 and DQ[beta]1 typing was performed at the two-digit level by PCR in randomly selected 54 GBS patients and 202 controls.Results [ndash] Fc[gamma]RIIA-H/H (56% vs 9%; P < 0.0001) and Fc[gamma]RIIIA-V/V (40% vs 13%; P < 0.0001) genotypes, H131 allele frequencies (0.73 vs 0.26, P < 0.0001) and HLA DQ[beta]1*060x (OR, 1.96; 95% CI, 1.26[ndash]3.04; P < 0.01) were significantly increased in GBS than controls. DR[beta]1*0701 alone (OR, 10; 95% CI, 45.90[ndash]2.25; P < 0.001) and together with Fc[gamma]RIIA-H/H (OR, 11.03; 95% CI, 2.63[ndash]46.20; P < 0.001) was significantly associated with GBS patients having microbiological evidence of recent infection.Conclusions [ndash] The study indicates that homozygous Fc[gamma]RIIA and Fc[gamma]RIIIA genotypes and Fc[gamma]RIIA H131 allele are associated with GBS. HLA class II molecule DR[beta]1*0701 is identified as novel genetic risk factor for development of GBS in patients with preceding infection.
