Imaging analysis of the brain in a primate model of cerebral malaria
June 5th, 2009 Posted by: admin
Publication year: 2009
Source: Acta Tropica, In Press, Accepted Manuscript, Available online 23 May 2009
Satoru, Kawai , Munehiro, Sugiyama
This paper reviews our studies concerning imaging analysis of the brain in a primate model of cerebral malaria. To elucidate the clinical features of cerebral malaria, we performed positron emission tomography with 18F-fluorodeoxyglucose (FDG-PET) scanning and magnetic resonance imaging (MRI) of the brain in Japanese macaques (Macaca fuscata) infected with Plasmodium coatneyi, a primate model of severe human malaria with cerebral involvement. On FDG-PET scanning, we observed diffuse and heterogeneous reduction of metabolism in the cerebral cortex in the acute phase of malaria infection. Although the monkey exhibited severe clinical signs, MR imaging did not reveal any significant changes during…
