"iDoctor – Medical Blog"

Rogojan C, Frederiksen JL. Hematopoietic stem cell transplantation in multiple sclerosis.Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2009.01168.x.© 2009 The Authors Journal compilation © 2009 Blackwell Munksgaard. Intensive immunosuppresion followed by hematopoietic stem cell transplantation (HSCT) has been suggested as potential treatment in severe forms of multiple sclerosis (MS). Since 1995 ca. 400 patients have been treated with HSCT. Stabilization or improvement occurred in almost 70% of cases at least for 3 years post-transplant. Magnetic resonance revealed the capacity of autologous HSCT to suppress or markedly reduce gadolinium-enhancing lesions. The progression of brain atrophy declined after two years post-HSCT. The profound immunological changes following autologous HSCT may result in restoration of self-tolerance. Relatively young patients with activ

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