Genetic diversity and population structure of Schistosoma mansoni within human infra-populations in Mwea, central Kenya assessed by microsatellite markers
June 5th, 2009 Posted by: admin
Publication year: 2009
Source: Acta Tropica, In Press, Accepted Manuscript, Available online 7 May 2009
L.E., Agola , M.L., Steinauer , D.N., Mburu , B.N., Mungai , I.N., Mwangi , …
A recently developed high-throughput technique that allows multi-locus microsatellite analysis of individual miracidia of Schistosoma mansoni was used to assess the levels of genetic diversity and population structure in 12 infrapopulations of the parasite, each infrapopulation derived from an infected school child from the Mwea area, central Kenya. The mean number of alleles per locus was in the range 8.22–10.22, expected heterozygosity in Hardy-Weinberg equilibrium was 0.68–0.70, and pair wise FST values ranged from 0.16–3.98% for the 12 infrapopulations. Although the genetic diversity within each infrapopulation of S. mansoni in this area was generally high, low levels of genetic structure…
