Fasting urine pH is independent of insulin sensitivity.
December 26th, 2009 Posted by: admin
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Fasting urine pH is independent of insulin sensitivity.
Am J Clin Nutr. 2009 Dec 23;
Authors: Workeneh B, Abbasi F, Reaven G
BACKGROUND: It has recently been suggested that a low urine pH be added to the abnormalities linked to insulin resistance. This conclusion is based on the finding of a low urine pH in individuals with clinical syndromes associated with insulin resistance and not on studies in which a direct measure of insulin sensitivity was shown to be significantly related to differences in urine pH. OBJECTIVE: To address this issue, we quantified insulin-mediated glucose uptake (IMGU) by using the insulin suppression test in 96 apparently healthy, nondiabetic individuals and defined its relation to fasting urine pH. DESIGN: Urine samples were collected and analyzed from a cohort of healthy subjects within a narrow body mass index range who were recruited to determine insulin sensitivity. RESULTS: There was an approximate 6-fold variation in values for IMGU in this population, with no relation to urine pH (r = 0.02). Furthermore, there was no relation between body mass index, as a surrogate estimate of insulin resistance, and urine pH (r = 0.06). CONCLUSION: On the basis of these findings, we question the view that a low urine pH be added to the abnormalities linked to insulin resistance in low-risk populations.
PMID: 20032494 [PubMed - as supplied by publisher]
