Efficacy of High-Dose Clopidogrel Treatment (600 mg) Less Than Two Hours Before Percutaneous Coronary Intervention in Patients With Non–ST-Segment Elevation Acute Coronary Syndromes
December 23rd, 2009 Posted by: admin
Publication year: 2009
Source: The American Journal of Cardiology, In Press, Corrected Proof, Available online 22 December 2009
Dmitriy N., Feldman , Foluso, Fakorede , Robert M., Minutello , Geoffrey, Bergman , Issam, Moussa , …
Current guidelines recommend pretreatment with a loading dose of clopidogrel before percutaneous coronary intervention (PCI) to reduce the incidence of periprocedural myocardial infarctions in patients undergoing PCI. However, because of concerns about postoperative bleeding, clopidogrel loading is frequently administered either immediately before or after PCI. Using the 2004/2005 Cornell Angioplasty Registry, we analyzed 1,041 consecutive patients undergoing urgent PCI for non–ST-elevation acute coronary syndrome. The patients were divided into 2 groups. The first group was the “preangiography clopidogrel therapy” group for those receiving chronic 75-mg clopidogrel therapy or receiving a clopidogrel loading dose (300 mg ≥12 hours or 600 mg…
