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Publication year: 2009
Source: The American Journal of Geriatric Pharmacotherapy, Volume 7, Issue 2, April 2009, Pages 74-83
Lori A., Daiello , Brian R., Ott , Kate L., Lapane , Steven E., Reinert , Jason T., Machan , …

Background: Cholinesterase inhibitors (CHEIs) ameliorate some types of behavioral symptoms in patients with Alzheimer’s disease. However, there has been little previous study of the outcomes associated with discontinuing these medications.Objective: The primary aim of this study was to evaluate the extent to which discontinuing CHEI therapy affected behavioral and mood symptoms in a cohort of nursing home residents with a diagnosis of dementia compared with residents receiving longer-term CHEI therapy.Methods: This was a retrospective cohort study using Rhode Island Medicaid prescription claims and the Minimum Data Set (MDS). Participants were Rhode Island nursing home residents aged ≥60 years with a…

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