Effect of Beta-Blocker Therapy on Rehospitalization Rates in Women Versus Men With Heart Failure and Preserved Ejection Fraction
January 1st, 2010 Posted by: admin
Publication year: 2010
Source: The American Journal of Cardiology, Volume 105, Issue 2, 15 January 2010, Pages 229-234
S. Morteza, Farasat , Dennis T., Bolger , Veena, Shetty , Elizabeth P., Menachery , Gary, Gerstenblith , …
Beta blockers are empirically used in many patients with heart failure (HF) and preserved ejection fraction (HFpEF) because they allow more time for diastolic filling and because they improve outcomes in patients with systolic HF. However, recent data suggest that impaired chronotropic and vasodilator responses to exercise, which can worsen with β blockade, may play a key role in the pathophysiology of HFpEF. We prospectively examined the association between β-blocker therapy after hospitalization for decompensated HF and HF rehospitalization at 6 months in 66 consecutive patients with HFpEF (71 ± 13 years old, 68% women, 42% Black). Subjects were stratified…
