"iDoctor – Medical Blog"

Yousefipour G, Erfani N, Momtahan M, Moghaddasi H, Ghaderi A. CTLA4 exon 1 and promoter polymorphisms in patients with multiple sclerosis.Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2009.01177.x.© 2009 The Authors Journal compilation © 2009 Blackwell Munksgaard.Objective [ndash] The polymorphisms of exon 1 (+49 A/G) and promoter regions ([minus]1722 T/C, [minus]1661 A/G and [minus]318 C/T)of cytotoxic T lymphocyte antigen 4 (CTLA4) and also haplotypes constructed from mentioned loci were investigated amongst 153 Iranian patients with definite multiple sclerosis (MS) and 190 healthy controls.Methods [ndash] The polymorphisms were genotyped by PCR-restriction fragment length polymorphisms and PCR-amplification refractory mutation system. The 4-locus haplotypes were estimated by Arlequin software (University of Be

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