"iDoctor – Medical Blog"

Hydrogen sulfide, which causes oral malodour, is generally produced from l-cysteine by the action of [beta]C[ndash]S lyase from oral bacteria. The [beta]C[ndash]S lyases from two oral bacteria, Streptococcus anginosus and S. gordonii, have been cloned, overproduced, purified and crystallized. X-ray diffraction data were collected from the two types of crystals using synchrotron radiation. The crystal of S. anginosus[beta]C[ndash]S lyase belonged to the orthorhombic space group P212121, with unit-cell parameters a = 67.0, b = 111.1, c = 216.4 Å, and the crystal of S. gordonii[beta]C[ndash]S lyase belonged to the same space group, with unit-cell parameters a = 58.0, b = 73.9. c = 187.6 Å. The structures of the [beta]C[ndash]S lyases were solved

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