"iDoctor – Medical Blog"

Publication year: 2009<br><b>Source:</b> The American Journal of Geriatric Pharmacotherapy, Volume 7, Issue 4, August 2009, Pages 197-203<br>Julio A., Leey , Steve, McCabe , Jennifer A., Koch , Toni P., Miles<br><br>Background: In patients with atrial fibrillation (AF), anticoagulation with warfarin decreases the risk of embolic stroke by >50%. Identification of genetic polymorphisms in enzymes involved in the metabolism of warfarin can partially predict the maintenance dose and thus potentially decrease the incidence of bleeding episodes secondary to warfarin overdose.Objectives: The objectives of this study were to evaluate the potential clinical and economic outcomes of genotype-guided warfarin therapy in elderly patients newly diagnosed with AF and to ident

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