Comparison of Usefulness of Simvastatin 20 mg Versus 80 mg in Preventing Contrast-Induced Nephropathy in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention
Publication year: 2009<br><b>Source:</b> The American Journal of Cardiology, Volume 104, Issue 4, 15 August 2009, Pages 519-524<br>Jia, Xinwei , Fu, Xianghua , Zhang, Jing , Gu, Xinshun , Xue, Ling , …<br><br>Contrast-induced nephropathy limits the outcomes of percutaneous coronary intervention (PCI). The present study compared the protective effects of different statin doses on renal function. A total of 228 patients with acute coronary syndrome undergoing selective PCI were randomly divided into simvastatin 20-mg group (S20, n = 115) and simvastatin 80-mg group (S80, n = 113). Serum creatinine was measured at admission, the day of PCI, and 24 and 48 hours after PCI. The creatinine