Circulating Matrix Metalloproteinase-3 and Metalloproteinase-9 and Tissue Doppler Measures of Diastolic Dysfunction to Risk Stratify Patients With Systolic Heart Failure
February 7th, 2010 Posted by: admin
Publication year: 2010
Source: The American Journal of Cardiology, In Press, Corrected Proof, Available online 5 February 2010
Simona, Buralli , Frank Lloyd, Dini , Piercarlo, Ballo , Umberto, Conti , Paolo, Fontanive , …
Abnormal matrix metalloproteinase (MMP) activity and diastolic dysfunction may affect left ventricular (LV) remodeling and prognosis, but it is not known whether the combined evaluation of MMP-3 and MMP-9 and variables of diastolic dysfunction are useful for the risk stratification of patients with systolic heart failure (HF). Therefore, this study was designed to assess the value of combining circulating levels of MMPs and tissue Doppler measures of LV diastolic dysfunction to risk-stratify patients with systolic HF. Consecutive patients with systolic HF due to either ischemic or nonischemic cardiomyopathy (n = 134) and LV ejection fractions <45% were submitted to complete…
