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Publication year: 2010
Source: The American Journal of Geriatric Pharmacotherapy, Volume 8, Issue 1, February 2010, Page IFC

[No author name available]

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Publication year: 2010
Source: The American Journal of Geriatric Pharmacotherapy, Volume 8, Issue 1, February 2010, Pages 1-3

Joseph T., Hanlon

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Publication year: 2010
Source: The American Journal of Geriatric Pharmacotherapy, Volume 8, Issue 1, February 2010, Pages 4-33

Karen, Barnard , Cathleen, Colón-Emeric

Background: Vitamin D insufficiency is prevalent among older adults and may be associated with higher risk for cardiovascular (CV) disease, mortality, depression, and cognitive deficits.Objective: The aim of this article was to review published observational and experimental studies that explored the association between vitamin D insufficiency and CV disease, mortality, mood, and cognition with an emphasis on older adults.Methods: PubMed and Web of Science databases were searched for English-language articles from January 1966 through June 2009 relating to vitamin D, using the following MeSH terms: aged, vitamin D deficiency, physiopathology, drug therapy, cardiovascular diseases, blood pressure, mortality, delirium, dementia, cognitive…

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Publication year: 2010
Source: The American Journal of Geriatric Pharmacotherapy, Volume 8, Issue 1, February 2010, Pages 34-46

Richard H., Lee , Kenneth W., Lyles , Cathleen, Colón-Emeric

Background: Osteoporosis and seizure disorders are common diagnoses in older adults and often occur concomitantly.Objective: The goal of this review was to discuss the current hypothesis for the pathogenesis of anticonvulsantinduced bone density loss and the evidence regarding the risk for osteoporosis and fractures in older individuals.Methods: A review of the literature was performed, searching in MEDLINE and CINAHL for articles published between 1990 and October 2009 with the following search terms: anticonvulsant OR antiepileptic; AND osteoporosis OR bone density OR fracture OR absorptiometry, photon. Studies within the pediatric population, cross-sectional studies, and studies whose results were published in a…

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Publication year: 2010
Source: The American Journal of Geriatric Pharmacotherapy, Volume 8, Issue 1, February 2010, Pages 47-62

Horatio B., Fung , Maricelle O., Monteagudo-Chu

Background: Community-acquired pneumonia (CAP) is a frequent cause of hospitalization and death among the elderly.Objective: This article reviews information on CAP among the elderly, including age-related changes, predisposing risk factors, causes, treatment strategies, and prevention.Methods: Searches of MEDLINE (January 1990-November 2009), International Pharmaceutical Abstracts (January 1990-November 2009), and Google Scholar were conducted using the terms community-acquired pneumonia, pneumonia, treatment guidelines, and elderly. Additional publications were found by searching the reference lists of the identified articles. Studies that reported diagnostic criteria as well as the treatment outcomes achieved in adult patients with CAP were selected for this review.Results: Three practice guidelines,…

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Publication year: 2010
Source: The American Journal of Geriatric Pharmacotherapy, Volume 8, Issue 1, February 2010, Pages 63-72

Lisa L., Dwyer , Beth, Han , David A., Woodwell , Elizabeth A., Rechtsteiner

Background: Despite the need for and benefits of medications, polypharmacy (defined here as concurrent use of ≥9 medications) in nursing home residents is a concern. As the number of medications taken increases, so does the risk for adverse events. Monitoring polypharmacy in this population is important and can improve the quality of nursing home care.Objectives: The aims of this article were to estimate the use of polypharmacy in residents of nursing homes in the United States, to examine the associations between select resident and facility characteristics and polypharmacy, and to determine the leading therapeutic subclasses included in the polypharmacy received…

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Publication year: 2010
Source: The American Journal of Geriatric Pharmacotherapy, Volume 8, Issue 1, February 2010, Pages 73-76

Robi, Goswami , David, Van De Car , Kenneth E., Schmader , Thomas M., Bashore , Michael H., Sketch Jr

Background: Ranolazine is increasingly being prescribed for the treatment of chronic stable angina. This report describes an adverse effect that may be related to ranolazine.Case summary: A 77-year-old white man with chronic renal insufficiency was evaluated for moderate dyspnea on exertion (DOE). Cardiac and pulmonary workup revealed nonobstructive coronary artery disease and mild obstructive lung disease. The patient had been taking ranolazine 500 mg daily for possible angina for the past 2 months. Given the temporal association of his symptoms with drug initiation, ranolazine was discontinued during the hospitalization. One month after discontinuing ranolazine, the patient’s DOE had completely resolved;…

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Publication year: 2010
Source: The American Journal of Geriatric Pharmacotherapy, Volume 8, Issue 1, February 2010, Pages 77-83

Zachary A., Marcum , Steven M., Handler , Richard, Boyce , Walid, Gellad , Joseph T., Hanlon

Objective: This paper reviews recent articles examining medication misadventures that can be defined as medication errors and adverse drug events in the elderly.Methods: MEDLINE and International Pharmaceutical Abstracts were searched for articles published in English in 2009 using a combination of the terms medication errors, medication adherence, suboptimal prescribing, monitoring, adverse drug events, adverse drug withdrawal events, therapeutic failure, and aged. A manual search of the reference lists of the identified articles and the authors’ article files, book chapters, and recent reviews was conducted to identify additional publications. Those studies that described unique approaches to evaluating medication misadventures in the…

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Publication year: 2010
Source: The American Journal of Geriatric Pharmacotherapy, Volume 8, Issue 1, February 2010, Pages 84-85

[No author name available]

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Publication year: 2010
Source: The American Journal of Geriatric Pharmacotherapy, Volume 8, Issue 1, February 2010, Pages 86-96

David R.P., Guay

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