A review of the effect of anticonvulsant medications on bone mineral density and fracture risk
March 15th, 2010 Posted by: admin
Publication year: 2010
Source: The American Journal of Geriatric Pharmacotherapy, Volume 8, Issue 1, February 2010, Pages 34-46
Richard H., Lee , Kenneth W., Lyles , Cathleen, Colón-Emeric
Background: Osteoporosis and seizure disorders are common diagnoses in older adults and often occur concomitantly.Objective: The goal of this review was to discuss the current hypothesis for the pathogenesis of anticonvulsantinduced bone density loss and the evidence regarding the risk for osteoporosis and fractures in older individuals.Methods: A review of the literature was performed, searching in MEDLINE and CINAHL for articles published between 1990 and October 2009 with the following search terms: anticonvulsant OR antiepileptic; AND osteoporosis OR bone density OR fracture OR absorptiometry, photon. Studies within the pediatric population, cross-sectional studies, and studies whose results were published in a…
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