A-G-4G haplotype of PAI-1 gene polymorphisms −844 G/A, HindIII G/C, and −675 4G/5G is associated with increased risk of ischemic stroke caused by small vessel disease
June 4th, 2009 Posted by: admin
Adamski MG, Turaj W, Slowik A, Wloch-Kopec D, Wolkow P, Szczudlik A. A-G-4G haplotype of PAI-1 gene polymorphisms [minus]844 G/A, HindIII G/C, and [minus]675 4G/5G is associated with increased risk of ischemic stroke caused by small vessel disease.Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2008.01127.x.© 2008 The Authors Journal compilation © 2008 Blackwell Munksgaard.Background [ndash] Plasminogen activator inhibitor type 1 (PAI-1) is the major inhibitor of fibrinolysis. It was reported that PAI-1 gene polymorphisms affected PAI-1 level and might therefore influence the risk of vascular diseases, including stroke. We studied the association of three common polymorphisms in PAI-1 gene ([minus]844 G/A, [minus]675 4G/5G, and HindIII G/C) with the odds of different causes of ischemic stroke.Methods [ndash] We studied 390 patients with ischemic stroke due to large vessel disease (n = 117), small vessel disease (n = 121), and cardioembolism (n = 152) as well as 291 controls. The etiology of ischemic stroke was established using TOAST criteria. PAI-1 polymorphisms were genotyped with restriction fragment length polymorphism and single strand conformation polymorphism method.Results [ndash] A-G-4G haplotype of PAI-1 gene was found more frequently in stroke patients with small vessel disease than in control subjects (44.9% vs 35.7%; P = 0.02). No association was found between investigated genotype or allele frequencies and distinct causes of ischemic stroke.Conclusions [ndash] Our results demonstrate that A-G-4G PAI-1 gene haplotype is associated with increased risk of small vessel disease stroke, but this study does not support an association of [minus]844 G/A, [minus]675 4G/5G, and HindIII G/C PAI-1 gene polymorphisms with particular etiology of ischemic stroke.
