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Effects of atorvastatin and n-3 fatty acid supplementation on VLDL apolipoprotein C-III kinetics in men with abdominal obesity.

Am J Clin Nutr. 2010 Feb 24;

Authors: Chan DC, Nguyen MN, Watts GF, Ooi EM, Barrett PH

BACKGROUND: Disturbed apolipoprotein (apo) C-III metabolism in obese subjects may account for hypertriglyceridemia and increased risk of cardiovascular disease. Atorvastatin and fish oils decrease plasma triglycerides and VLDL concentrations, but the underlying mechanisms are not fully understood. OBJECTIVE: We studied the independent and combined effects of atorvastatin and fish oils on the metabolism of VLDL apo C-III in obese men. DESIGN: We carried out a 6-wk randomized, placebo-controlled, 2 x 2 factorial intervention study of atorvastatin (40 mg/d) and fish oils (4 g/d) on VLDL apo C-III kinetics in the postabsorptive state in 39 abdominally obese men using intravenous administration of d(3)-leucine. VLDL apo C-III isotopic enrichments were measured by using gas chromatography-mass spectrometry with kinetic parameters derived by using a multicompartmental model. RESULTS: Atorvastatin significantly (P < 0.05, main effect) increased the VLDL apo C-III fractional catabolic rate (+0.06 +/- 0.003 pools/d) without significantly altering its production rate (-0.14 +/- 0.18 mg kg(-1) d(-1)), accounting for a significant reduction in plasma VLDL apo C-III pool size (-44 +/- 17 mg/L). Fish-oil supplementation significantly decreased plasma triglycerides but did not significantly alter plasma VLDL apo C-III concentrations or kinetic parameters. Combination treatment provided no additional effect on VLDL apo C-III concentrations or kinetics compared with atorvastatin alone. CONCLUSIONS: In obesity, the triglyceride-lowering effect of atorvastatin, but not fish oils, is associated with increased VLDL apo C-III fractional catabolism and hence lower VLDL apo C-III concentrations. Combination treatment provided no significant additional improvement in VLDL apo C-III metabolism compared with atorvastatin alone.

PMID: 20181806 [PubMed - as supplied by publisher]

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Publication year: 2010
Source: The American Journal of Cardiology, Volume 105, Issue 5, 1 March 2010, Page A4

[No author name available]

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Publication year: 2010
Source: The American Journal of Cardiology, Volume 105, Issue 5, 1 March 2010, Pages A7, A12, A17

[No author name available]

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Publication year: 2010
Source: The American Journal of Cardiology, Volume 105, Issue 5, 1 March 2010, Pages 611-618

Tomasz, Kurek , Radosław, Lenarczyk , Jacek, Kowalczyk , Andrzej, Świątkowski , Oskar, Kowalski , …

The significance of anemia in patients with acute myocardial infarction (AMI) treated with percutaneous coronary intervention (PCI) remains controversial. The aim of the present study was to evaluate the effect of anemia on the short- and long-term prognosis of patients with AMI treated with PCI, including high-risk subgroups. The study group consisted of 1,497 consecutive patients with AMI treated in the acute phase with PCI. Anemia was defined using World Health Organization criteria (hemoglobin level <13 g/dl for men and <12 g/dl for women). The study population was divided into 2 major groups (patients with [n = 248, 16.6%] and…

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Publication year: 2010
Source: The American Journal of Cardiology, Volume 105, Issue 5, 1 March 2010, Pages 619-623

Subroto, Acharjee , Jie, Qin , Sabina A., Murphy , Carolyn, McCabe , Christopher P., Cannon

Current guidelines recommend risk stratification largely based on traditional risk factors such as those in the Framingham Risk Score. We studied the distribution of 12 traditional and non-traditional risk markers (age ≥65 years, male gender, family history of premature coronary heart disease, low-density lipoprotein cholesterol ≥70 mg/dl, high-density lipoprotein cholesterol <40 mg/dl in men and 130 mm Hg, diabetes mellitus, smoking, C-reactive protein ≥2 mg/L, triglycerides >150 mg/dl, prediabetes defined as a fasting glucose level 100 to 125 mg/dl or hemoglobin A1c >6, and obesity defined as body mass index ≥30 kg/m2) in…

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Publication year: 2010
Source: The American Journal of Cardiology, Volume 105, Issue 5, 1 March 2010, Pages 624-628

Takeshi, Senoo , Masayuki, Motohiro , Hiroshi, Kamihata , Satoshi, Yamamoto , Tsuyoshi, Isono , …

Contrast-induced nephropathy (CIN) is associated with significantly increased morbidity and mortality after coronary angiography and percutaneous coronary intervention (PCI). The aim of the present study was to assess the clinical features and in-hospital outcomes of CIN after emergency PCI. The serum creatinine (SCr) concentration was measured from days 0 to 30 in 338 consecutive patients with acute coronary syndrome undergoing emergency PCI. CIN was defined as an increase in SCr of >25% or >0.5 mg/dl within 2 days after PCI. Overall, 94 patients (28%) developed CIN. The mean SCr on admission was not significantly different between patients with CIN and…

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Publication year: 2010
Source: The American Journal of Cardiology, Volume 105, Issue 5, 1 March 2010, Pages 629-632

Yuichi J., Shimada , Navin C., Nakra , John T., Fox , Yumiko, Kanei

A weight-adjusted bolus of heparin (70 to 100 IU/kg) is recommended to achieve adequate anticoagulation during percutaneous coronary intervention (PCI). Proper dosing is mandatory to avoid bleeding and thrombotic complications. We investigated whether sensitivity to heparin is affected by difference in race. We performed a retrospective study with 874 consecutive PCI cases in our catheterization laboratory. The amount of initial heparin bolus (international units) per weight and subsequent activated clotting time (ACT; seconds) were obtained. Patients were divided into 4 categories based on race: Asian, African-American, European-American, and Hispanic. Multiple regression analysis was performed to validate the variables that determine…

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Publication year: 2010
Source: The American Journal of Cardiology, Volume 105, Issue 5, 1 March 2010, Pages 633-639

Martin, Noël , Jean, Jobin , Audrey, Marcoux , Paul, Poirier , Gilles, Dagenais , …

We previously observed an attenuation of exercise-induced myocardial ischemia on the ergocycle during a ramp protocol compared to the standard Bruce protocol treadmill test in patients with coronary heart disease. However, it was uncertain whether decreased ischemia on the ergocycle resulted from the warm-up effect of the more gradual ramp protocol or from the mode of exercise itself (cycling vs running). Sixteen stable patients, aged 64 ± 5 years, with documented coronary heart disease (≥70% coronary artery stenosis and/or reversible myocardial perfusion defects) performed 3 symptom-limited exercise tests: the standard Bruce protocol treadmill test and 2 individualized ramp protocols (treadmill…

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Publication year: 2010
Source: The American Journal of Cardiology, Volume 105, Issue 5, 1 March 2010, Pages 640-644

Andrea, Ballotta , Marco, Ranucci , Alessia, Kunkl , Hisham, El Baghdady , Eduardo, Bossone , …

N-terminal pro–brain natriuretic peptide (NT–pro-BNP) levels have been shown to be increased at baseline in patients undergoing surgical ventricular restoration (SVR) of the left ventricle. However, changes in the values of this marker in the early postoperative period and its prognostic significance remain less known in these patients. We evaluated 31 consecutive patients undergoing SVR who had NT–pro-BNP determined a day before SVR and from postoperative days 0 to 4. Major morbidity was defined as ≥1 of the following: ventilation >48 hours, stroke, acute renal failure, low cardiac output, reoperation, or mediastinitis. The association of preoperative NT–pro-BNP with perioperative outcomes…

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Publication year: 2010
Source: The American Journal of Cardiology, Volume 105, Issue 5, 1 March 2010, Pages 645-655

Daniele, Andreini , Gianluca, Pontone , Saima, Mushtaq , Mauro, Pepi , Antonio Luca, Bartorelli

The investigators conducted a review to evaluate the diagnostic performance of multidetector computed tomography (MDCT) for coronary stent evaluation. The prespecified inclusion criteria selected prospective or retrospective human studies published in English. Studies that did not report raw numbers of diagnostic accuracy for the detection of in-stent restenosis were excluded. The data from 24 studies are reported, 6 performed with old-generation scanners (4-, 16-, and 40-slice MDCT) and 18 performed with 64-slice MDCT or dual-source MDCT. With old-generation MDCT, up to 18% of coronary stents were missed, the rate of nonevaluable stents ranged from 2.6% to 23.5%, and the overall…

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