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Publication year: 2009
Source: The American Journal of Geriatric Pharmacotherapy, Volume 7, Issue 6, December 2009, Pages 343-354

Nour A., Obeidat , Françoise G., Pradel , Ilene H., Zuckerman , Sylvain, DeLisle , C. Daniel, Mullins

Background: Several population-based studies have confirmed the benefits of adjuvant chemotherapy with 5-fluorouracil/leucovorin for treatment of colorectal cancer. Few population-based studies have evaluated other chemotherapies that are now available for colorectal cancer management.Objective: This study primarily sought to evaluate the survival benefit of first-line irinotecan use in a group of Medicare patients with stage IV (metastatic) colorectal cancer.Methods: Data on chemotherapy users with a diagnosis of colorectal cancer reported between 1998 and 2002 were obtained from the Surveillance Epidemiology and End Results (SEER)-Medicare database. Irinotecan, marketed in 1997, was one of the newer chemotherapy agents in the available data. Chemotherapy…

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Publication year: 2009
Source: The American Journal of Geriatric Pharmacotherapy, Volume 7, Issue 6, December 2009, Pages 355-361

J., Simon Bell , Timo, Klaukka , Jouni, Ahonen , Sirpa, Hartikainen

Background: The use of opioids has increased rapidly in Europe and North America, and older people may be susceptible to opioid-related adverse drug events. The Finnish National Agency for Medicines has recommended that oral opioids be considered the first-line treatment when a strong opioid is required for severe pain.Objective: The objective of this study was to investigate and describe the age-, indication-, sex-, and geographic-specific utilization of transdermal fentanyl among older people residing in noninstitutional settings in Finland.Methods: Reimbursement data for fentanyl, morphine, oxycodone, and hydromorphone were extracted from the Finnish National Prescription Register for 2008. Age-specific population data were…

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Publication year: 2009
Source: The American Journal of Geriatric Pharmacotherapy, Volume 7, Issue 6, December 2009, Pages 362-372

Mary T., Roth , Lea C., Watson , Denise A., Esserman , Jena L., Ivey , Richard, Hansen , …

Background: Medication-related problems are prevalent in older adults, contributing to increased harm and health care costs and negatively impacting quality of care. Older adults with psychiatric disease are at an increased risk because of their underlying disease and types of medications prescribed. Efforts to improve the quality of medication use often focus on select medication-related problems, select diagnoses, or predefined quality indicators; however, such an approach fails to consider the potential for multiple coexisting problems within individuals.Objective: A pilot study was conducted to test the feasibility of a medication management program designed to improve the quality of medication use in…

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Publication year: 2009
Source: The American Journal of Geriatric Pharmacotherapy, Volume 7, Issue 6, December 2009, Pages 373-382

Norman, Zinner , Les, Noe , Lawrence, Rasouliyan , Thomas, Marshall , M., Christopher Runken , …

Background: Overactive bladder (OAB) is a common problem among the elderly and a financial burden to society. The prevalence of OAB increases with age and affects ≥25% of people aged ≥65 years.Objective: The goal of this exploratory subgroup analysis of the VESIcare Efficacy and Research Study US (VERSUS) was to assess changes in health-related quality of life (HRQoL), medical care resource utilization, work and activity impairment, and health utility among elderly patients with OAB who continued to have urgency symptoms with tolterodine and were willing to try solifenacin.Methods: This was a 12-week, multicenter, prospective, open-label, noncomparative, flexible-dosing study designed to…

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Publication year: 2009
Source: The American Journal of Geriatric Pharmacotherapy, Volume 7, Issue 6, December 2009, Pages 383-392

Mitchell A.H., Levine , Shuang, Xu , Katherine, Gaebel , Nicole, Brazier , Michel, Bédard , …

Background: The self-reported use of natural health products (NHPs) (herbal products and vitamin and mineral supplements) has increased over the past decade in Canada. Because the elderly population might have comorbidities and concurrently administered medications, there is a need to explore the perceptions and behaviors associated with NHPs in this age group.Objective: The goal of this study was to assess the use of NHPs in a cohort of older Canadian residents and the characteristics, perceptions, and behaviors associated with NHP use.Methods: Survey participants aged ≥60 years were randomly selected from telephone listings in the area of greater Hamilton, Ontario, Canada….

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Publication year: 2009
Source: The American Journal of Geriatric Pharmacotherapy, Volume 7, Issue 6, December 2009, Page 401

[No author name available]

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Publication year: 2009
Source: The American Journal of Geriatric Pharmacotherapy, Volume 7, Issue 6, December 2009, Pages 402-405

[No author name available]

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• Content Type Journal Article
• Category Original Paper
• DOI 10.1007/s10464-009-9285-1
• Authors
  • Richard A. Jenkins, National Institute on Drug Abuse, National Institutes of Health Prevention Research Branch 6001 Executive Blvd., Rm. 5185 MSC 9589 Bethesda MD 20892-9589 USA

• Journal American Journal of Community Psychology
• Online ISSN 1573-2770
• Print ISSN 0091-0562

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• Content Type Journal Article
• Category Original Paper
• DOI 10.1007/s10464-009-9283-3
• Authors
  • Christopher K. Burke, University of Texas Health Science Center at San Antonio Department of Psychiatry San Antonio TX USA
  • Kenneth I. Maton, University of Maryland, Baltimore County Human Services Psychology Department, MP 313 1000 Hilltop Circle Catonsville MD 21250 USA
  • Eric S. Mankowski, Portland State University Portland OR USA
  • Clinton Anderson, American Psychological Association Washington DC USA

• Journal American Journal of Community Psychology
• Online ISSN 1573-2770
• Print ISSN 0091-0562

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Sinha S, Prasad KN, Jain D, Nyati KK, Pradhan S, Agrawal S. Immunoglobulin IgG Fc-receptor polymorphisms and HLA class II molecules in Guillain[ndash]Barré syndrome.Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2009.01229.x.© 2010 The Authors Journal compilation © 2010 Blackwell Munksgaard.Objective [ndash] To analyze host genetic factors immunoglobulin G Fc receptors (Fc[gamma]Rs) and human leukocyte antigen (HLA) class II in GBS patients.Methods [ndash] Fc[gamma]RIIA, IIIA and IIIB polymorphisms were studied in 80 each GBS patients and healthy controls by allele specific PCR. HLA class II DR[beta]1 and DQ[beta]1 typing was performed at the two-digit level by PCR in randomly selected 54 GBS patients and 202 controls.Results [ndash] Fc[gamma]RIIA-H/H (56% vs 9%; P < 0.0001) and Fc[gamma]RIIIA-V/V (40% vs 13%; P < 0.0001) genotypes, H131 allele frequencies (0.73 vs 0.26, P < 0.0001) and HLA DQ[beta]1*060x (OR, 1.96; 95% CI, 1.26[ndash]3.04; P < 0.01) were significantly increased in GBS than controls. DR[beta]1*0701 alone (OR, 10; 95% CI, 45.90[ndash]2.25; P < 0.001) and together with Fc[gamma]RIIA-H/H (OR, 11.03; 95% CI, 2.63[ndash]46.20; P < 0.001) was significantly associated with GBS patients having microbiological evidence of recent infection.Conclusions [ndash] The study indicates that homozygous Fc[gamma]RIIA and Fc[gamma]RIIIA genotypes and Fc[gamma]RIIA H131 allele are associated with GBS. HLA class II molecule DR[beta]1*0701 is identified as novel genetic risk factor for development of GBS in patients with preceding infection.

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